Иванова Светлана Александровна

Доктор медицинских наук, профессор, заместитель директора по научной работе НИИ психического здоровья Томского НИМЦ, заведующая лабораторией молекулярной генетики и биохимии НИИ психического здоровья, профессор ИШНКБ Томского политехнического университета.

 

Контактная информация: ivanovaniipz@gmail.com

 

Область научных интересов: Биологическая психиатрия, молекулярная генетика, фармакогенетика, биохимия, биомаркеры психических расстройств, трансляционная психиатрия.

Избранные публикации:

 

 — Blood-Derived RNA- and microRNA-Hydrolyzing IgG Antibodies in Schizophrenia Patients. Ermakov EA, Ivanova SA, Buneva VN, Nevinsky GA Biochemistry (Mosc). 2018 May;83(5):507-526. doi: 10.1134/S0006297918050048

 — Remaining Need for In Vitro Test to Elucidate 5-Hydroxytryptamine 2C Receptor Functioning. Ivanova SA, Dröge MJ, Volders HH, van Vliet BJ, Bokhan NA, Bosker FJ, Loonen AJM J Clin Psychopharmacol. 2018 Aug;38(4):410-411. doi: 10.1097/JCP.0000000000000914.

 — The functional variant rs334558 of GSK3B is associated with remission in patients with depressive disorders. Levchenko A, Losenkov IS, Vyalova NM, Simutkin GG, Bokhan NA, Wilffert B, Loonen AJ, Ivanova SA. Pharmgenomics Pers Med. 2018 Jul 20;11:121-126. doi: 10.2147/PGPM.S171423. eCollection 2018.

 — Hydrolysis by catalytic IgGs of microRNA specific for patients with schizophrenia. Ermakov EA, Ivanova SA, Buneva VN, Nevinsky GA. IUBMB Life. 2018 Feb;70(2):153-164. doi: 10.1002/iub.1712.

 — Parkinson’s disease and polymorphisms of the glutamatergic system genes GRIN2A, SLC1A2, and GRIK4 Mironova, Yu.S., Zhukova, I.A., Zhukova, N.G., Ivanova S.A., Alifirova V.M., Boiko A.S., Osmanova D.Z., Izhboldina, O.P., Latypova, A.V. Nevrologiya, Neiropsikhiatriya, Psikhosomatika 2018;10(2):27–32. DOI: 10.14412/2074-2711-2018-2-27-32

 — Association of polymorphic variants of PIP5K2A and HTR2C genes with response to antidepressant therapy of patients with a current depressive episode. Vyalova NM, Pozhidaev IV, Osmanova DZ, Simutkin GG, Ivanova SА, Bokhan NA. Zh Nevrol Psikhiatr Im S S Korsakova. 2017;117(5):58-61. doi: 10.17116/jnevro20171175158-61. Russian.

 — Ivanova S.A., Alifirova V.M., Pozhidaev I.V., Freidin M.B., Zhukova I.A., Osmanova D.Z., Zhukova N.G., Mironova Y.A., Tiguntsev V.V., Fedorenko O.Y., Bokhan N.A., Wilffert B., Loonen A.J.M. Polymorphisms of Catechol-O-Methyl Transferase (COMT) Gene in Vulnerability to Levodopa-Induced Dyskinesia. J Pharm Pharm Sci. 2018. Vol. 21(1):340-346. doi: 10.18433/jpps29903. (Web of Science IF 2.333; Scopus Q1)

 — Fattakhov N., Smirnova L., Atochin D., Parshukova D., Skuratovskaia D., Painter Q., Zatolokin P., Semke A., Litvinova L., Ivanova S. Haplotype analysis of endothelial nitric oxide synthase (NOS3) genetic variants and metabolic syndrome in healthy subjects and schizophrenia patients. Int J Obes (Lond). 2018. doi: 10.1038/s41366-018-0124-z. (Web of Science IF 5.487; Scopus Q1)

 — Association of Polymorphisms of Serotonin Transporter (5HTTLPR) and 5-HT2C Receptor Genes with Criminal Behavior in Russian Criminal Offenders. Toshchakova VA, Bakhtiari Y, Kulikov AV, Gusev SI, Trofimova MV, Fedorenko OY, Mikhalitskaya EV, Popova NK, Bokhan NA, Hovens JE, Loonen AJM, Wilffert B, Ivanova SA. Neuropsychobiology. 2017;75(4):200-210. doi: 10.1159/000487484

 — Association study of genetic markers of schizophrenia and its cognitive endophenotypes. Bocharova AV, Stepanov VA, Marusin AV, Kharkov VN, Vagaitseva KV, Fedorenko OY, Bokhan NA, Semke AV, Ivanova SA. Genetika. 2017 Jan;53(1):100-8. Russian. https://link.springer.com/article/10.1134/S1022795417010033

 — Ivanova, S. A., Osmanova, D. Z., Freidin, M. B., Fedorenko, O. Y., Boiko, A. S., Pozhidaev, I. V., Semke, A. V., Bokhan, N. A., Agarkov, A. A., Wilffert, B., Loonen A. J. Identification of 5-hydroxytryptamine receptor gene polymorphisms modulating hyperprolactinemia in antipsychotic drug-treated schizophrenic patients // World J. Biol. Psychiatry.– 2017 Apr;18(3):239-246. (IF 4.159) DOI: 10.1080/15622975.2016.1224926

 — Ivanova SA, Osmanova DZ, Boiko AS, Pozhidaev IV, Freidin MB, Fedorenko OY, Semke AV, Bokhan NA, Kornetova EG, Rakhmazova LD, Wilffert B, Loonen AJ. Prolactin gene polymorphism (-1149 G/T) is associated with hyperprolactinemia in patients with schizophrenia treated with antipsychotics. Schizophr Res. 2017 Apr;182:110-114. doi: 10.1016/j.schres.2016.10.029 (IF 4.453) URL: https://www.ncbi.nlm.nih.gov/pubmed/27776952

 — Albert Batalla, Judith R. Homberg, Tatiana V. Lipina, Guillaume Sescousse, Maartje Luijten, Svetlana A. Ivanova, Arnt F.A. Schellekens, Anton J.M. Loonen , The role of the habenula in the transition from reward to misery in substance use and mood disorders Neuroscience & Biobehavioral Reviews Available online 30 May 2017 Volume 80, September 2017, Pages 276–285 https://doi.org/10.1016/j.neubiorev.2017.03.019 (IF 8,55). URL: https://www.ncbi.nlm.nih.gov/pubmed/28576510

 — Geers LM, Cohen D, Wehkamp LM, van Hateren K, Koster RA, Fedorenko OY, Semke AV, Bokhan N, Ivanova SA, Kosterink JGW, Loonen AJM, Touw DJ. Dried Blood Spot Analysis for Therapeutic Drug Monitoring of Clozapine. J Clin Psychiatry. 2017 Oct 24. pii: 16m11164. doi: 10.4088/JCP.16m11164. (IF 5.291) URL: http://www.psychiatrist.com/JCP/article/Pages/2017/v78n09/16m11164.aspx

 — I.S. Losenkov, N.M. Vyalova, G.G. Simutkin, N.A. Bokhan, S.A. Ivanova An association of AKT1 gene polymorphism with antidepressant treatment response. The World Journal of Biological Psychiatry 2016 Volume 17, Issue 3, pages 239-242 (IF 4,15) URL: http://dx.doi.org/10.3109/15622975.2015.1112921

 — The association of the DRD3 gene with Parkinson’s disease. Ivanova SA, Alifirova VM, Zhukova IA, Boiko AS, Fedorenko OY, Zhukova NG, Bokhan NA. Zh Nevrol Psikhiatr Im S S Korsakova. 2016;116(5):71-74. doi: 10.17116/jnevro20161165171-74. Russian. doi: 10.17116/jnevro20161165171-74.

 — Ivanova SA, Toshchakova VA, Filipenko ML, Fedorenko OY, Boyarko EG, Boiko AS, Semke AV, Bokhan NA, Aftanas LI, Loonen AJ. Cytochrome P450 1A2 co-determines neuroleptic load and may diminish tardive dyskinesia by increased inducibility. World J Biol Psychiatry. 2015 Apr;16(3):200-5. (IF 4,15) URL: http://dx.doi.org/10.3109/15622975.2014.995222    

 — CYP1A2 and CYP2D6 Gene Polymorphisms in Schizophrenic Patients with Neuroleptic Drug-Induced Side Effects. Ivanova SA, Filipenko ML, Vyalova NM, Voronina EN, Pozhidaev IV, Osmanova DZ, Ivanov MV, Fedorenko OY, Semke AV, Bokhan NA. Bull Exp Biol Med. 2016 Mar;160(5):687-90. doi: 10.1007/s10517-016-3250-4

 — Fedorenko O.Y, Loonen A.J.M., Lang F., Toshchakova V.A., Boyarko E.G., Semke A.V., Bokhan N.A., Govorin N.V., Aftanas L.I., Ivanova S.A. Association study indicates a protective role of phosphatidylinositol-4-phosphate-5-kinase against tardive dyskinesia. Int J Neuropsychopharmacol. 2015. 18 (6) p.1-6: (IF 4.333).         DOI: http://dx.doi.org/10.1093/ijnp/pyu098

 — Ivanova SA, Loonen AJ, Bakker PR, Freidin MB, Ter Woerds NJ, Al Hadithy AF, Semke AV, Fedorenko OY, Brouwers JR, Bokhan NA, van Os J, van Harten PN, Wilffert B. Likelihood of mechanistic roles for dopaminergic, serotonergic and glutamatergic receptors in tardive dyskinesia: A comparison of genetic variants in two independent patient populations. SAGE Open Med. 2016 Apr 11;4:2050312116643673. doi: 10.1177/2050312116643673. URL: http://journals.sagepub.com/doi/pdf/10.1177/2050312116643673

 — Svetlana A. Ivanova, Anton J. M. Loonen Levodopa-Induced Dyskinesia Is Related to Indirect Pathway Medium Spiny Neuron Excitotoxicity: A Hypothesis Based on an Unexpected Finding, Parkinson’s Disease, vol. 2016, Article ID 6461907, 5 pages, 2016. doi:10.1155/2016/6461907. (IF 2,010). URL: https://www.ncbi.nlm.nih.gov/pubmed/27144051

Ivanova S.A., Geers L.M., Al Hadithy A.F., Pechlivanoglou P., Semke A.V., Vyalova N.M., Rudikov E.V., Fedorenko O.Y., Wilffert B., Bokhan N.A., Brouwers J.R., Loonen A.J. Dehydroepiandrosterone sulphate as a putative protective factor against tardive dyskinesia. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2014 Apr 3; 50: 172-7. (IF 4,361) DOI: 10.1016/j.pnpbp.2013.12.015

  — Association of (N251S)-PIP5K2A with schizophrenic disorders: a study of the Russian population of Siberia. Fedorenko OIu, Rudikov EV, Gavrilova VA, Boiarko EG, Semke AV, Ivanova SA. Zh Nevrol Psikhiatr Im S S Korsakova. 2013;113(5):58-61. Russian. https://www.ncbi.nlm.nih.gov/pubmed/23739505

 — Anton J. M. Loonen, Svetlana A. Ivanova New insights into the mechanism of drug-induced dyskinesia. CNS Spectrums 2013 Volume 18   Issue 01 pp 15-20 (IF3,589) DOI: http://dx.doi.org/10.1017/S1092852912000752

 — Ivanova S.A., Al Hadithy A.F., Brazovskaya N., Semke A., Wilffert B., Fedorenko O., Brouwers J.R., Loonen A.J. No involvement of the adenosine A2A receptor in tardive dyskinesia in Russian psychiatric inpatients from Siberia. Hum Psychopharmacol. 2012. V. 27. N. 3. P. 334—337. (IF 2,44) DOI: 10.1002/hup.2226

 — Ivanova S. A., Loonen A. J. M., Pechlivanoglou P., Freidin M. B., Al Hadithy A. F. Y, Rudikov E. V., Zhukova I. A., Govorin N. V., Sorokina V. A., Fedorenko O., Alifirova V. M., Semke A. V., Brouwers J. R. B. J., Wilffert B. NMDA receptor genotypes associated with the vulnerability to develop dyskinesia. Transl Psychiatry. 2012 Jan 10;2:e67 (IF 5,538). DOI: 10.1038/tp.2011.66  URL: http://www.nature.com/tp/journal/v2/n1/full/tp201166a.html

 — Al Hadithy A. F. Y., Ivanova S. A., Pechlivanoglou P., Semke A., Fedorenko O., Kornetova E., Ryadovaya L., Brouwers J. R. B. J., Loonen A. J. M. Missense polymorphisms in three oxidative-stress enzymes (GSTP1, SOD2, and GPX1) and dyskinesias in Russian psychiatric inpatients from Siberia. Hum. Psychopharmacol. Clin. ExP. 2010. V. 25. N. 1. P. 84—91 (IF 2,44). DOI: 10.1002/hup.1087

 — Hadithy A.F.Y. Al, Ivanova S.A., Pechlivanoglou P., Semke A., Fedorenko O., Kornetova E., Ryadovaya L., Brouwers J.R.B.J., Wilffert B., Bruggeman R., Loonen A.J.M. Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia// Progress in Neuro-Psychopharmacology & Biological Psychiatry.- 2009.- N.33.- P. 475–481. (IF 4.361). DOI: 10.1016/j.pnpbp.2009.01.010

 — Fedorenko O., Tang C., Sopjani M., Föller M., Gehring E.-M., Strutz-Seebohm N., Ureche O.N., Ivanova S., Semke A., Lang F., Seebohm G., Lang U.E. PIP5K2A-dependent regulation of excitatory amino acid transporter EAAT3 // Psychopharmacology.- 2009.- V.206.- N3- P429-435. (IF 3.540). DOI: 10.1007/s00213-009-1621-5