MD, PhD, Leading Researcher of the Laboratory of Molecular Genetics and Biochemistry, Mental Health Research Institute, Tomsk National Research Medical Center of Russian Academy of Sciences; Professor at the School of Non-Destructive Testing & Security, National Research Tomsk Polytechnic University.

 

Contact information: f_o_y@mail.ru

 

Research interests: Biological psychiatry, molecular genetics, pharmacogenetics, biochemistry, biomarkers of mental disorders, translational psychiatry.

 

Selected publications:

 

— Fedorenko O.Yu., Golimbet V.E., Ivanova S.А., Levchenko А., Gainetdinov R.R., Semke A.V., Simutkin G.G., Gareeva А.E., Glotov А.S., Gryaznova A., Iourov I.Y., Krupitsky E.M., Lebedev I.N., Mazo G.E., Kaleda V.G., Abramova L.I., Oleichik I.V., Nasykhova Yu.A., Nasyrova R.F., Nikolishin A.E., Kasyanov E.D., Rukavishnikov G.V., Timerbulatov I.F., Brodyansky V.M., Vorsanova S.G., Yurov Yu.B., Zhilyaeva T.V., Sergeeva  A.V., Blokhina E.A.,  Zvartau E.E., Blagonravova  A.S., Aftanas L.I., Bokhan N.А., Kekelidze Z.I., Klimenko T.V., Anokhina I.P., Khusnutdinova E.K., Klyushnik T.P., Neznanov N.G., Stepanov V.A., Schulze T.G., Kibitov А.О. Opening up new horizons for psychiatric genetics in the Russian Federation: moving toward a national consortium // Molecular Psychiatry 2019 Jan 21:1-13. doi: 10.1038/s41380-019-0354-z. (Web of Science IF 11.640)

— Boiko A.S., Ivanova S.A., Pozhidaev I.V., Freidin M.B., Osmanova D.Z., Fedorenko O.Yu., Semke A.V., Bokhan N.A.,  Wilffert B., Loonen A.J.M. Pharmacogenetics of tardive dyskinesia in schizophrenia: the role of  CHRM1 and CHRM2 muscarinic receptors // The World Journal of Biological Psychiatry 2019 Jan 9:1-6. doi: 10.1080/15622975.2018.1548780. (Web of Science IF 4.225)

— Levchenko A., Vyalova N.M., Pozhidaev I.V., Boiko A.S., Osmanova D.Z., Fedorenko O.Yu., Semke А.V., Bokhan N.A., Wilffert B., Loonen A.J.M., Ivanova S.A. No evidence so far of a major role of AKT1 and GSK3B in the pathogenesis of antipsychotic-induced tardive dyskinesia // Human Psychopharmacology 2019 Jan;34(1):e2685. doi: 10.1002/hup.2685. (Web of Science IF 2.86)

 — Ivanova S.A., Alifirova V.M., Pozhidaev I.V., Freidin M.B., Zhukova I.A., Osmanova D.Z., Zhukova N.G., Mironova Y.A., Tiguntsev V.V., Fedorenko O.Y., Bokhan N.A., Wilffert B., Loonen A.J.M. Polymorphisms of Catechol-O-Methyl Transferase (COMT) Gene in Vulnerability to Levodopa-Induced Dyskinesia. J Pharm Pharm Sci. 2018. 21(1):340-346. doi: 10.18433/jpps29903. (Web of Science IF 2.333; Scopus Q1)

 — Toshchakova VA, Bakhtiari Y, Kulikov AV, Gusev SI, Trofimova MV, Fedorenko OY, Mikhalitskaya EV, Popova NK, Bokhan NA, Hovens JE, Loonen AJM, Wilffert B, Ivanova SA. Association of Polymorphisms of Serotonin Transporter (5HTTLPR) and 5-HT2C Receptor Genes with Criminal Behavior in Russian Criminal Offenders. Neuropsychobiology. 2017;75(4):200-210. doi: 10.1159/000487484

 — Bocharova AV, Stepanov VA, Marusin AV, Kharkov VN, Vagaitseva KV, Fedorenko OY, Bokhan NA, Semke AV, Ivanova SA. Association study of genetic markers of schizophrenia and its cognitive endophenotypes. Genetika. 2017. 53(1):100-8. Russian. https://link.springer.com/article/10.1134/S1022795417010033

— Geers LM, Cohen D, Wehkamp LM, van Hateren K, Koster RA, Fedorenko OY, Semke AV, Bokhan N, Ivanova SA, Kosterink JGW, Loonen AJM, Touw DJ. Dried Blood Spot Analysis for Therapeutic Drug Monitoring of Clozapine // J Clin Psychiatry. 2017. 78(9):e1211-e1218. doi: 10.4088/JCP.16m11164. (Web of Science IF 5.498)

 — Ivanova, S. A., Osmanova, D. Z., Freidin, M. B., Fedorenko, O. Y., Boiko, A. S., Pozhidaev, I. V., Semke, A. V., Bokhan, N. A., Agarkov, A. A., Wilffert, B., Loonen A. J. Identification of 5-hydroxytryptamine receptor gene polymorphisms modulating hyperprolactinemia in antipsychotic drug-treated schizophrenic patients // World J. Biol. Psychiatry.– 2017;18(3):239-246. (Web of Science IF 4.159) DOI: 10.1080/15622975.2016.1224926

 — Ivanova SA, Osmanova DZ, Boiko AS, Pozhidaev IV, Freidin MB, Fedorenko OY, Semke AV, Bokhan NA, Kornetova EG, Rakhmazova LD, Wilffert B, Loonen AJ. Prolactin gene polymorphism (-1149 G/T) is associated with hyperprolactinemia in patients with schizophrenia treated with antipsychotics. Schizophr Res. 2017;182:110-114. doi: 10.1016/j.schres.2016.10.029 (Web of Science IF 4.453) URL: https://www.ncbi.nlm.nih.gov/pubmed/27776952

 — The association of the DRD3 gene with Parkinson’s disease. Ivanova SA, Alifirova VM, Zhukova IA, Boiko AS, Fedorenko OY, Zhukova NG, Bokhan NA. Zh Nevrol Psikhiatr Im S S Korsakova. 2016;116(5):71-74. doi: 10.17116/jnevro20161165171-74. Russian. doi: 10.17116/jnevro20161165171-74.

 — Ivanova SA, Toshchakova VA, Filipenko ML, Fedorenko OY, Boyarko EG, Boiko AS, Semke AV, Bokhan NA, Aftanas LI, Loonen AJ. Cytochrome P450 1A2 co-determines neuroleptic load and may diminish tardive dyskinesia by increased inducibility. World J Biol Psychiatry. 2015;16(3):200-5. (Web of Science IF 4,15) URL: http://dx.doi.org/10.3109/15622975.2014.995222    

 — Ivanova SA, Filipenko ML, Vyalova NM, Voronina EN, Pozhidaev IV, Osmanova DZ, Ivanov MV, Fedorenko OY, Semke AV, Bokhan NA. CYP1A2 and CYP2D6 Gene Polymorphisms in Schizophrenic Patients with Neuroleptic Drug-Induced Side Effects. Bull Exp Biol Med. 2016;160(5):687-90. doi: 10.1007/s10517-016-3250-4

 — Fedorenko O.Y, Loonen A.J.M., Lang F., Toshchakova V.A., Boyarko E.G., Semke A.V., Bokhan N.A., Govorin N.V., Aftanas L.I., Ivanova S.A. Association study indicates a protective role of phosphatidylinositol-4-phosphate-5-kinase against tardive dyskinesia. Int J Neuropsychopharmacol. 2015. 18 (6) p.1-6: (Web of Science IF 4.333).         DOI: http://dx.doi.org/10.1093/ijnp/pyu098

 — Ivanova SA, Loonen AJ, Bakker PR, Freidin MB, Ter Woerds NJ, Al Hadithy AF, Semke AV, Fedorenko OY, Brouwers JR, Bokhan NA, van Os J, van Harten PN, Wilffert B. Likelihood of mechanistic roles for dopaminergic, serotonergic and glutamatergic receptors in tardive dyskinesia: A comparison of genetic variants in two independent patient populations. SAGE Open Med. 2016 Apr 11;4:2050312116643673. doi: 10.1177/2050312116643673. URL: http://journals.sagepub.com/doi/pdf/10.1177/2050312116643673

 — Ivanova S.A., Geers L.M., Al Hadithy A.F., Pechlivanoglou P., Semke A.V., Vyalova N.M., Rudikov E.V., Fedorenko O.Y., Wilffert B., Bokhan N.A., Brouwers J.R., Loonen A.J. Dehydroepiandrosterone sulphate as a putative protective factor against tardive dyskinesia. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2014; 50: 172-7. (Web of Science IF 4,361) DOI: 10.1016/j.pnpbp.2013.12.015

— Lou Q., Hansen B.J., Fedorenko O., Csepe T.A., Kalyanasundaram A., Hage L.T., Glukhov A.V., Billman G/E., Weiss R., Mohler P.J., Gyorke S., Biesiadecki B.J., Carnes C.A., Fedorov V.V. Upregulation of adenosine A1 receptors facilitates sinoatrial node dysfunction in chronic canine heart failure by exacerbating nodal conduction abnormalities revealed by novel dual-sided intramural optical mapping // Circulation.- 2014. V. 130. N. 4. P. 315-324. doi: 10.1161/CIRCULATIONAHA. (Web of Science IF 15.202).

— Yanni J., Maczewski M., Mackiewicz U., Siew S.,  Fedorenko O., Atkinson A., Price M., Beresewicz A., Anderson R. H., Boyett M. R.,  Dobrzynski H. Structural and functional alterations in the atrioventricular node and atrioventricular ring tissue in ischaemia-induced heart failure // Histology and Histopathology.– 2014.– N. 7.– P.891—902. (Web of Science IF 2.281).

— Fedorenko OIu, Rudikov EV, Gavrilova VA, Boiarko EG, Semke AV, Ivanova SA. Association of (N251S)-PIP5K2A with schizophrenic disorders: a study of the Russian population of Siberia. Zh Nevrol Psikhiatr Im S S Korsakova. 2013;113(5):58-61. Russian. https://www.ncbi.nlm.nih.gov/pubmed/23739505

  — Atkinson AJ, Logantha SJ, Hao G, Yanni J, Fedorenko O, Sinha A, Gilbert SH, Benson AP, Buckley DL, Anderson RH, Boyett MR, Dobrzynski H. Functional, anatomical, and molecular investigation of the cardiac conduction system and arrhythmogenic atrioventricular ring tissue in the rat heart // J Am Heart Assoc. – 2013.- V. 2.- N.6:e000246. doi: 10.1161/JAHA.113.000246. (Web of Science IF 2.882).

— Ivanova S.A., Al Hadithy A.F., Brazovskaya N., Semke A., Wilffert B., Fedorenko O., Brouwers J.R., Loonen A.J. No involvement of the adenosine A2A receptor in tardive dyskinesia in Russian psychiatric inpatients from Siberia. Hum Psychopharmacol. 2012. V. 27. N. 3. P. 334—337. (Web of Science IF 2,44) DOI: 10.1002/hup.2226

 — Ivanova S. A., Loonen A. J. M., Pechlivanoglou P., Freidin M. B., Al Hadithy A. F. Y, Rudikov E. V., Zhukova I. A., Govorin N. V., Sorokina V. A., Fedorenko O., Alifirova V. M., Semke A. V., Brouwers J. R. B. J., Wilffert B. NMDA receptor genotypes associated with the vulnerability to develop dyskinesia. Transl Psychiatry. 2012 Jan 10;2:e67 (Web of Science IF 5,538). DOI: 10.1038/tp.2011.66  URL: http://www.nature.com/tp/journal/v2/n1/full/tp201166a.html

 — Al Hadithy A. F. Y., Ivanova S. A., Pechlivanoglou P., Semke A., Fedorenko O., Kornetova E., Ryadovaya L., Brouwers J. R. B. J., Loonen A. J. M. Missense polymorphisms in three oxidative-stress enzymes (GSTP1, SOD2, and GPX1) and dyskinesias in Russian psychiatric inpatients from Siberia. Hum. Psychopharmacol. Clin. ExP. 2010. V. 25. N. 1. P. 84—91 (Web of Science IF 2,44). DOI: 10.1002/hup.1087

 — Hadithy A.F.Y. Al, Ivanova S.A., Pechlivanoglou P., Semke A., Fedorenko O., Kornetova E., Ryadovaya L., Brouwers J.R.B.J., Wilffert B., Bruggeman R., Loonen A.J.M. Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia// Progress in Neuro-Psychopharmacology & Biological Psychiatry.- 2009.- N.33.- P. 475–481. (Web of Science IF 4.361). DOI: 10.1016/j.pnpbp.2009.01.010

 — Fedorenko O., Tang C., Sopjani M., Föller M., Gehring E.-M., Strutz-Seebohm N., Ureche O.N., Ivanova S., Semke A., Lang F., Seebohm G., Lang U.E. PIP5K2A-dependent regulation of excitatory amino acid transporter EAAT3 // Psychopharmacology.- 2009.- V.206.- N3- P429-435. (Web of Science IF 3.540). DOI: 10.1007/s00213-009-1621-5

— Fedorenko O., Strutz-Seebohm N., Henrion U., Ureche O., Seebohm G., Lang F. A., Lang U. E. Schizophrenia-linked mutation in PIP5K2A fails to activate neuronal M-channels in Xenopus oocytes // Psychopharmacology. 2008. V. 199. N. 1. P. 47—54 (Web of Science IF 3.988).

— Frey A., Lampert A., Dietz K., Striebich S., Locher C., Fedorenko O., Möhle R., Gallinat J., Lang F., Lang U. E. Thyrotropin serum concentrations in healthy volunteers are associated with depression-related personality traits // Neuropsychobiology. 2007. V. 56. N. 2–3. P. 123—126 (Web of Science IF 1.992). — Strutz-Seebohm N., Seebohm G., Fedorenko O., Baltaev R., Engel J., Knirsch M., Lang F. Functional coassembly of KCNQ4 with KCNE-beta-subunits in Xenopus oocytes // Cell. Physiol. Biochem. 2006. V. 18. N.1–3. P. 57—66 (Web of Science IF 3.56).